THE ASSOCIATION OF VITAMIN D WITH OVERWEIGHT AND LIPID PROFILE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

Authors

  • Arkhypkina T. L. V. Danilevsky Institute of Endocrine Pathology Problems of NAMS Ukraine, Kharkov, Ukraine
  • Lyubimovа L. P. V. Danilevsky Institute of Endocrine Pathology Problems of NAMS Ukraine, Kharkov, Ukraine
  • Bondarenko V. A. V. Danilevsky Institute of Endocrine Pathology Problems of NAMS Ukraine, Kharkov, Ukraine https://orcid.org/0000-0002-9254-3875
  • Yeromenko R. F. National Pharmaceutical University, Ministry of Health of Ukraine, Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2020.4.01

Keywords:

polycystic ovary syndrome, vitamin D, overweight, blood lipid spectrum

Abstract

The aim of the work was to study the relationship between levels of vitamin D, obesity and lipid profile
in patients with polycystic ovary syndrome (PCOS).
Materials and methods. The study involved 120 women: 60 patients with PCOS and 60 healthy women.
All examined were divided into groups depending on body mass index (BMI): patients with PCOS — 30 with
BMI ≤ 25 kg/m2
and 30 with BMI ≥ 25 kg/m2; healthy women — 30 with BMI ≤ 25 kg/m2
and 30 with
BMI ≥ 25 kg/m2.
Results. Patients with a BMI of ≥ 25 kg/m2
had a lower average level of vitamin D (P < 0,001) than patients
with a BMI of ≤ 25 kg/m2; among of them there was a higher percentage of women with a pronounced
deficiency (23.3% versus 13.3%) and deficiency (60% versus 50%) of vitamin D; nobody had not adequate levels
of vitamin D. It was established a negative correlation between the level of vitamin D and BMI (r = – 0.275;
P < 0.05), waist circumference (r = – 0.604; P < 0.001), the coefficient of waist circumference/ hips circumference
(r = – 0.512; P < 0.001). Abdominal type of adipose tissue distribution, which was observed among patients with
both overweight and normal weight, may be one of the factors contributing to dysregulation of metabolism of vitamin
D in conditions of PCOS.
Women with PCOS had lipid metabolism disorders with increased atherogenic and decreased levels of antiatherogenic
lipid fractions wich was intensif with increasing body weight. It was established a negative correlation
between the level of vitamin D and triglycerides (r = – 0.437; P < 0.001), and positive association with high
density lipoprotein cholesterol (r = 0.492; P < 0.001).
In healthy women, only a negative correlation between the concentration of vitamin D and BMI (r = – 0.562;
P < 0.001) was establish and there was no association with other anthropometric indicators and indicators of the
blood lipid spectrum.
Conclusion. Patients with PCOS have a higher prevalence and severity of deficiency of vitamin D.
Disruption of regulation of vitamin D metabolism may be a consequence of existing obesity, and a decrease in
vitamin D levels is an additional factor that increase the dyslipidemia that exists in PCOS.

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Published

2021-06-30

How to Cite

Arkhypkina, T. L., Lyubimovа L. P., Bondarenko, V. A., & Yeromenko, R. F. (2021). THE ASSOCIATION OF VITAMIN D WITH OVERWEIGHT AND LIPID PROFILE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME. Problems of Endocrine Pathology, 74(4), 7-14. https://doi.org/10.21856/j-PEP.2020.4.01

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Section

CLINICAL ENDOCRINOLOGY

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