MAGNESIUM DEFICIENCY AT ENDOCRINE PATHOLOGY AND WAYS OF ITS CORRECTION
Keywords:magnesium deficiency, endocrine pathology, Magne B6
Among the main elements contained in the human body, magnesium is recognized as one of the most important. This is confirmed by the uneven distribution of this element with preferential deposition in tissues with
high metabolic activity, the participation of magnesium in energy processes, in the synthesis and degradation
of a number of neurotransmitters, as well as in the regulation of neurochemical transmission and muscle excitability. Being a calcium antagonist, magnesium also has cardio- and vasoprotective effects. Magnesium deficiency is manifested by a wide range of symptoms indicating multi-organ disorders of the whole organism. On
the one hand, according to the role of magnesium in the production of a number of hormones during hypomagnesemia insulin synthesis disorders, insulin resistance, depletion of adrenal cortex function, increased release
of catecholamines, and hyperthyroidism are revealed. On the other hand, endocrine diseases such as diabetes
mellitus, hyperthyroidism, hyperparathyroidism, primary hyperaldosteronism and obesity lead to magnesium
deficiency. In type 1 and type 2 diabetes mellitus magnesium deficiency contributes to the development of arterial hypertension, acute coronary events with the occurrence of fatal arrhythmias and an increased risk of
thrombosis. Magnesium-deficient conditions in obesity are detected in most patients, and surgical treatment of
obesity leads to a significant deficiency of magnesium in 100% of cases. In toxic goiter latent or apparent deficiency of magnesium in the body is manifested in 100% of cases too. With the development of hypothyroidism
the occurrence of magnesium-deficient conditions is due to reduced absorption of magnesium through the swollen mucosa of the digestive tract. In addition, with a deficiency of thyroid hormones magnesium does not enter
into enzymatic reactions. Timely and adequate correction of magnesium imbalance in patients with endocrine
pathology is very important. An example of a tool that can restore the level of magnesium in the body and level
the manifestations of hypomagnesemia is a dietary supplement Magne B6 TM BBpharm
Trisvetova EL. Racional’naja Farmakoterapija v Kardiologii 2012; 8(4): 545-553.
Al Alawi AM, Majoni SW, Falhammar H. Int J Endocrinol 2018; 2018: 9041694. doi: http://doi.org/10.1155/2018/9041694.
Saris NE, Mervaala E, Karppanen H, et al. Clin Chim Acta 2000;294: 1-26. doi: http://doi.org/10.1016/s0009-8981(99)00258-2
Efstratiadis G, Sarigianni M, Gougourelas I. Hippokratia 2006; 10(04): 147-152.
Rosanoff A. Clin Calcium 2005; 15: 255-260.
Lybova LT. Liky Ukrai’ny 2014; 7-8(183-184): 82-86.
Martin KJ, Gonzalez EA, Slatopolsky E. J Am Soc Nephrol 2009; 20(11): 2291-2295. doi: http://doi.org/10.1681/ASN.2007111194
Swaminathan R. Clin Biochem Rev 2003; 24(2): 47-66.
Grigus JI, Mihajlova OD, Gorbunov AJ, Vahrushev JM. Jeksperimen Klinich Gastrojenterol 2015; 118(6): 89-94.
Tereshhenko IV. Klinich Medicina 2008; 7: 47-5111.
Gunther T. Magnes. Res 2010; 23(1): 5-18. doi: http://doi.org/10.1684/ mrh.2009.0195
Grober U, Schmidt J, Kisters K. Nutrients 2015; 7(9): 8199-8226. doi: http://doi.org/ 10.3390/nu7095388