DISBALANCE OF ADYPOKINS AND INDICATORS OF SYSTEMIC IMMUNO-INFLAMMATORY ACTIVATION IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION AND OBESITY
Keywords:arterial hypertension, obesity, adipokines, cytokines
The aim of the work was to evaluate the levels of adiponectin, leptin, CRP and IL-6 in patients with essential hypertension with concomitant obesity. We examined 80 patients with hypertension and obesity, which were divided into three groups depending on the degree of obesity: 40 patients with obesity I degree, 22 patients — II degree and 18 patients — III degree. The comparison group was 40 patients with arterial hypertension without obesity. The level of adiponectin in patients of the main group was significantly lower than in the comparator group (p < 0.001). In obese patients, there was a higher concentration of leptin (p < 0.001) compared with patients without obesity. The level of IL-6 and CRP in obese patients with hypertension was significantly higher (p < 0.001), compared to the comparison group. In patients with obesity of the III degree, the level of adiponectin was lower (p < 0.001) compared with healthy subjects and the comparison group (p < 0.001). The level of leptin was found to be highest in patients with obesity of the third degree, exceeding its concentration in healthy subjects by 3.16 times (p < 0.001) and 2.77 times (p < 0.001) in the level of comparison. Also, in patients with obesity of the third grade, the level of IL-6 was the highest, significantly exceeding the similar indicator in the healthy group and in the comparison group. The CRP concentration was highest at the third stage of obesity, exceeding the CRP of healthy (p < 0.001) and comparison groups (p < 0.001). Between adiponectin and IL-6, the correlation of the mean strength (r = –0.42, p = 0.01) was found, as well as a reverse correlation connection of strong force between the adiponectin and leptin (r = –0.79 , p = 0.001). Essential arterial hypertension with obesity has more severe course than without concomitant pathology and is characterized by higher rates of indicators of systemic immuno-inflammatory activation and pathological values of leptin and adiponectin.
Robocha hrupa z arterialnoi hipertenzii ukrainskoi asotsiatsii kardiolohiv. Arterіa’na Hіpertenzіia 2018;
Sirenko YuM. Arteryalna Hypertenzyia 2018; 3 (59): 19-22.
Ambrosova TM, Kovalova OM. Eksperym Klin Medytsyna 2012; 3 (56): 99-105.
Gelsinger C, Tschoner A, Kaser S. Wien Med Wochenschr 2010; 160 (15-16): 377-390. https://doi.org/10.1007/s10354-010-0781-6.
Skybchyk VA, Skybchyk YaV. Ukr Med Chasopys 2012; 6 (62): 45-51.
Strilchuk LM. Arterialna Hipertenziia 2017; 3 (53): 71-72.
Mitchenko OI, Romanov VIu, Yanovska KO. Ukr Kardiol Zhurn 2012; 2: 40-47.
Babak OIa, Andrieieva AO. Ukr Terapevtych Zhur 2013; 1: 63-67.
Mishchenko LA, Svishchenko YeP, Bezrodnyi VP. Halytskyi Likar Visn 2012; 19 (4): 55-58.
Stadnik SM. Liky Ukrainy 2013; 9-10 (175-176): 30-34.
Vizir VA, Honcharov OV, Sadomov AS. Zaporozh Med Zhurn 2013; 4 (79): 5-9.
Radchenko OM, Kit ZM, Radchenko LM. Bukovyn Med Visn 2013; 17 (4): 117-120.