The relationship between blood lipid profile and uricemia levels in patients with type 2 diabetes mellitus according to gender

Authors

  • Cherniaieva A. O. Kharkiv medical Academy of postgraduate education of the Ministry of health of Ukraine, Kharkov, Ukraine; SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine
  • Mykytyuk M. R. Kharkiv medical Academy of postgraduate education of the Ministry of health of Ukraine, Kharkov, Ukraine
  • Karachentsev Y. I. Kharkiv medical Academy of postgraduate education of the Ministry of health of Ukraine, Kharkov, Ukraine; SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine
  • Kravchun N. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2019.3.11

Keywords:

hyperuricemia, type 2 diabetes mellitus, dyslipidemia

Abstract

The purpose of the study was to determine the incidence of hyperuricemia and to analyze the relationship between blood lipid profile and uric acid values in patients with type 2 diabetes mellitus according to gender. 161 patients with type 2 diabetes (67 men and 94 women) who received oral glucose-lowering therapy were examined. In the overall sample, 88 % of men and 95.7 % of women were over 50 years of age. Given the level of uric acid in the blood, patients were divided into groups: 1A (n = 43) — with blood uric acid level within the reference values for men (< 420 мmol/l), 1B (n = 24) — the blood uric acid level was above the upper limit of the reference value for men (> 420 мmol/l), 2A (n = 54) — with blood uric acid level within the reference values for women ( 350 мmol/l). BMI in women was significantly higher than in men (33.83 ± 6.6) and (30.83 ± 4.5) kg/m2 (P = 0.001); IOT/ OS was significantly higher in males ((1.03 ± 0.11) and (0.97 ± 0.10) cu, respectively (P = 0.003). Significantly higher levels of cholesterol were observed in women than in men ((1.17 ± 0.29) and (1.06 ± 0.16) mmol/l, respectively (P = 0.006). Hyperuricemia was diagnosed in 39.8% of patients in the total sample. Comparison of the frequency of hyperuricemia in men and women revealed no significant differences (35.8 and 42.6%, respectively). In normouricemic male patients with type 2 diabetes mellitus, the level of CHD was associated with the age and blood level of uric acid; HDL-cholesterol level — with age, disease duration and blood level of uric acid; TG level — with the level of uric acid in the blood. In normouricemic female patients with type 2 diabetes mellitus, CSF level was associated with HbAc1 level; the level of HDL-cholesterol — with age and BMI; TG level — with the blood level of uric acid. The level of HDL-cholesterol was associated with hyperuricemia in male patients with type 2 diabetes mellitus. The level of CHD, HDL-cholesterol and TG were independently associated with the level of glycemic control of the disease in «hyperuricemic» female patients with type 2 diabetes mellitus.

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Published

2019-08-28

How to Cite

Cherniaieva, A. O., Mykytyuk, M. R., Karachentsev, Y. I., & Kravchun, N. O. (2019). The relationship between blood lipid profile and uricemia levels in patients with type 2 diabetes mellitus according to gender . Problems of Endocrine Pathology, 69(3), 83-90. https://doi.org/10.21856/j-PEP.2019.3.11

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Section

CLINICAL ENDOCRINOLOGY

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