THE RELATIONSHIP BETWEEN BLOOD LIPID PROFILE AND URICEMIA LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ACCORDING TO GENDER
Keywords:hyperuricemia, type 2 diabetes mellitus, dyslipidemia
The purpose of the study was to determine the incidence of hyperuricemia and to analyze the relationship between blood lipid profile and uric acid values in patients with type 2 diabetes mellitus according to gender. 161 patients with type 2 diabetes (67 men and 94 women) who received oral glucose-lowering therapy were examined. In the overall sample, 88 % of men and 95.7 % of women were over 50 years of age. Given the level of uric acid in the blood, patients were divided into groups: 1A (n = 43) — with blood uric acid level within the reference values for men (< 420 мmol/l), 1B (n = 24) — the blood uric acid level was above the upper limit of the reference value for men (> 420 мmol/l), 2A (n = 54) — with blood uric acid level within the reference values for women ( 350 мmol/l). BMI in women was significantly higher than in men (33.83 ± 6.6) and (30.83 ± 4.5) kg/m2 (P = 0.001); IOT/ OS was significantly higher in males ((1.03 ± 0.11) and (0.97 ± 0.10) cu, respectively (P = 0.003). Significantly higher levels of cholesterol were observed in women than in men ((1.17 ± 0.29) and (1.06 ± 0.16) mmol/l, respectively (P = 0.006). Hyperuricemia was diagnosed in 39.8% of patients in the total sample. Comparison of the frequency of hyperuricemia in men and women revealed no significant differences (35.8 and 42.6%, respectively). In normouricemic male patients with type 2 diabetes mellitus, the level of CHD was associated with the age and blood level of uric acid; HDL-cholesterol level — with age, disease duration and blood level of uric acid; TG level — with the level of uric acid in the blood. In normouricemic female patients with type 2 diabetes mellitus, CSF level was associated with HbAc1 level; the level of HDL-cholesterol — with age and BMI; TG level — with the blood level of uric acid. The level of HDL-cholesterol was associated with hyperuricemia in male patients with type 2 diabetes mellitus. The level of CHD, HDL-cholesterol and TG were independently associated with the level of glycemic control of the disease in «hyperuricemic» female patients with type 2 diabetes mellitus.
Becker BF. Free Radic Biol Med 1993; 14(6): 615-631.
Brook RA, Forsythe A, Smeeding JE, et al. Curr Med Res Opin 2010; 26(12): 2813-2821.
Lehto S, Niskanen L, Rцnnemaa T, Laakso M. Stroke 1998; 29(3): 635-639.
Culleton BF, Larson MG, Kannel WB, Levy D. Ann Intern Med 1999; 131(1): 7-13.
Lu W, Song K, Wang Y, et al. J Clin Lipidol 2012; 6(2): 159-167. https://doi.org/10.1016/j.jacl.2011.11.006.
Akande AA, Jimoh AK, Akinyinka OA, Olarinoye GO. Niger J Clin Pract 2007; 10(2): 137-142.
World Health Organization. Obesity: Preventing and managing the global epidemic. Technical report series no 894, Geneva, 2000: 23 р.
Klimov AN, Nikul’cheva JuG. Obmen lipidov i lipoproteidov i ih narushenija, Sankt-Petreburg, 1999: 505 p.
American Diabetes Association. Diabetes Care 2000; 23(1): S57-S60. https://doi.org/10.2337/diacare.26.2007.s83.
Armitage P, Berry G. Statistical Methods in Medical Research, Cambridge, 1994: 620 p.
Woyesa SB, Hirigo AT, Wube TB. BMC Endocr Disord 2017; 17(1): 76. https://doi.org/10.1186/s12902-017-0226-y.
Sharma N, Rajkumari R, Anil B. Int J Adv Res 2015; 3(5): 289-296. https://doi.org/10.1186/1471-2458-4-9.
Mundhe SA, Dinkar RM. Int J Adv Med 2016; 3(2): 241-249. https://doi.org/10.18203/2349-3933.ijam20160655.
Li S, Yu C, Li Y, et al. J E vid B ased M ed 2018; 11(3): 152-157. https://doi.org/10.1111/jebm.12291.
Liu DM, Jiang LD, Gan L, et al. Endocr Pract 2019; 25(5): 438-445. https://doi.org/10.4158/ep-2018-0426.
Sarmah D, Sharma B. Asian J Med Sci 2013; 4(2): 8-14.
Wang J, Chen RP, Lei L, et al. Asia Pac J Clin Nutr 2013; 22(4): 590-598. https://doi.org/10.6133/apjcn.2013.22.4.16.
Cherniaieva A, Mykytyuk M, Karachentsev I, Kravchun N. Probl Endokryn Patologii 2019; 2: 73-80. https://doi.org/10.21856/j-PEP.2019.2.11.
Sharma N, Rajkumari R, Anil B. Int J Adv Res 2015; 3(5): 289-296. http://dx.doi.org/10.18203/2349-3933.ijam20160655.
Xin Zhang, Qingtao Meng, Jiayue Feng. Lipids Health Dis 2018; 17: 235. https://doi.org/10.1186/s12944-018-0882-6.