Frequency of combinations of different histological forms of papillary thyroid cancer with other diseases of the thyroid parenchyma

Authors

  • Karachentsev Yu. I. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Dubovik V. M. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Gopkalova I. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Khaziev V. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Goydenko N. I. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Korchagin Y. P. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Sazonov M. Y. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Gerasimenko L. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2019.1.03

Keywords:

thyroid gland, papillary carcinoma, autoimmune thyroiditis, colloid goiter, follicular adenoma, histological variants of thyroid papillary carcinoma

Abstract

The authors showed that in the prevailing majority of cases (71 %) papillary carcinomas were formed against the background of other thyroid diseases. In this work, the main forms of thyroid pathology, which is most often found in PTC, were identified and their frequency was determined. It has been proven that in 39.8 % of cases PTC was combined with only one of the following diseases: in 20 % with autoimmune thyroiditis, in 14.8 % with colloid goiter, in 5 % with follicular adenomas. The combination of PTC with not one, but with several thyroid pathologies is 31.4 %. Such a high frequency of combination of malignant and benign pathology in the thyroid gland suggests that the proliferative processes that result in benign diseases can change their direction and lead to the appearance of cells with signs of malignancy. That is, goitre-altered thyroid tissue is more sensitive to the action of various carcinogenic agents, such as radiation, toxic effects or impaired neuroendocrine regulation. In the analysis of histological forms of PTC, it was shown that AIT is more common in adenocarcinomas and PC from cylindrical cells, and colloid goiter in microscopic cancer and follicular PC. Follicular adenoma is more often associated with follicular PTC. We believe that the analysis will have value for the differential diagnosis of histological forms of papillary thyroid cancer.

References

Daniel R. J Surg Res 2008; 150 (1): 49-52. doi: http://doi.org/10.1016/j.jss.2007.09.020.

Okani CO, et al. Niger Med J 2015; 56 (6): 433-435.doi: 1http://doi.org/0.4103/0300-1652.171612.

Nikiforov YE. J Clin Endocrinol Metab 2006; 91 (6):2040-2042.

Kang DY, Kim KH, Kim JM, et al. Thyroid 2007;17 (11): 1031-1038.

Paparodis R, Imam S, Todorova-Koteva K, et al. Thyroid 2014; 24 (7): 1107-1114. doi: http://doi.org/10.1089/thy.2013.0588.

Anil C, Goksel S, Gursoy Anil A. Thyroid 2010; 20:601-606. doi:http://doi.org/ 10.1089/thy.2013.0588.

Krátký J. J Jiskra VnitřLék 2015; 61 (10): 878-881.

Akshay A, KulSingh R, Jitendra KK. Indian J Surg Oncol 2014; 5 (3): 199-204.

Kim SS. Head Neck 2011; 33 (9): 1272-1277. doi: http://doi.org/10.1002/hed.21594.

Aleksander K, Marcin B, Wojciech N, Wojciech W.Langenbecks Arch Surg 2014; 399 (2): 229-236.

Trunin EM, Kerimov JeS, Murt LL. Vestn c-peterb unta 2008; 2 (11): 104-110.

Ma H, et al. Pol J Pathol 2014; 65 (3): 202-209.

Kandalova IG. Uzlovaja transformacіja shhitovidnoj zhelezy na fone difuznogo toksicheskogo zoba, SanktPeterburg,2013: 142 р.

Trunin EM. Diffuznyj toksicheskij zob. Kompleksnaja diagnostika, konservativnaja terapija, hirurgicheskoe lechenie, Sankt-Peterburg, 2006: 182 р.

Merkulov GA. Kurs patogistologicheskoj tehniki, Leningrad,1969: 23.

Downloads

Published

2021-07-06

How to Cite

Karachentsev, Y. I. ., Dubovik, . V. M. ., Gopkalova, . I. V., Khaziev, V. V. ., Goydenko, N. I. ., Korchagin, Y. P., Sazonov, M. Y. ., & Gerasimenko, . L. V. (2021). Frequency of combinations of different histological forms of papillary thyroid cancer with other diseases of the thyroid parenchyma. Problems of Endocrine Pathology, 67(1), 23-29. https://doi.org/10.21856/j-PEP.2019.1.03

Issue

Section

CLINICAL ENDOCRINOLOGY

Most read articles by the same author(s)

1 2 > >>