Waist-to-hip ratio as a representative indicator for primary determination of risk group for non-alcoholic fatty liver disease women with type 2 diabetes mellitus

Authors

  • Plohotnichenko O. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems NAMS of Ukraine», Kharkiv, Ukraine
  • Tyzhnenko T. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems NAMS of Ukraine», Kharkiv, Ukraine
  • Gorshunska M. Y. Kharkiv Postgraduate Medical Academy, Kharkiv, Ukraine
  • Krasova N. S. SI «V. Danilevsky Institute for Endocrine Pathology Problems NAMS of Ukraine», Kharkiv, Ukraine
  • Leshchenko Zh. A. SI «V. Danilevsky Institute for Endocrine Pathology Problems NAMS of Ukraine», Kharkiv, Ukraine
  • Gladkih A. I. SI «V. Danilevsky Institute for Endocrine Pathology Problems NAMS of Ukraine», Kharkiv, Ukraine
  • Gromakovska O. B. SI «V. Danilevsky Institute for Endocrine Pathology Problems NAMS of Ukraine», Kharkiv, Ukraine
  • Poltorak V. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems NAMS of Ukraine», Kharkiv, Ukraine
  • Kravchun N. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2019.3.09

Keywords:

waist-to-hip ratio, type 2 diabetes, nonalcoholic fatty liver disease, diagnostic model

Abstract

In patients with type 2 diabetes mellitus complicated by nonalcoholic fatty liver disease (NAFLD) a pattern of biochemical and anthropometric measures, and their diagnostic value were studied. A significant increase in the waist-to-hip ratio (WHR) in the group of patients with NAFLD was found. In the course of further verification of the WHR diagnostic significance has been established that for men this indicator can not be considered as a risk factor for NAFLD. Using the logistic regression and Roc-analysis, a diagnostic model was developed for the allocation of risk groups for the development of NAFLD in women with type 2 diabetes under the WHR. Defined threshold value of the WHR — 0.93; sensitivity is 75%; specificity is 50%; PPV (positive prognostic value) — 44%, NPV (negative prognostic value) — 79%, аccuracy index — 58%. The calculation of the WHR is sufficiently informative, which makes it possible to use it in population surveys in obesity prevention programs, NAFLD, and type 2 diabetes mellitus. The model allows to form a risk group for NAFLD among women with type 2 diabetes using simple and affordable anthropometric indicator.

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Published

2019-08-28

How to Cite

Plohotnichenko, O. O., Tyzhnenko, T. V., Gorshunska, M. Y., Krasova, N. S., Leshchenko, Z. A., Gladkih, A. I., Gromakovska, O. B., Poltorak, V. V., & Kravchun, N. O. (2019). Waist-to-hip ratio as a representative indicator for primary determination of risk group for non-alcoholic fatty liver disease women with type 2 diabetes mellitus . Problems of Endocrine Pathology, 69(3), 66-73. https://doi.org/10.21856/j-PEP.2019.3.09

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Section

CLINICAL ENDOCRINOLOGY

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