Association of hypertleptinemia and gestational weight gain


  • Ostafiichuk S. O. Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
  • Henyk N. I. Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine



leptin, gestational weight gain, body fat mass


The aim of the study was to determine the dynamics of leptin plasma concentration in pregnant women, depending on gestational weight gain. This prospective study included 163 pregnant women who visited antenatal clinics in Ivano-Frankivsk, Ukraine during 2016–2018. The recommended GWG was diagnosed in 56 (34.4 %), insufficient in 33 (20.2 %) and excessive in 74 (45.4 %) patients, according to the recommendations of the Institute of Medicine (IOM) in the USA (2009) and the Order of the Ministry of Health of Ukraine № 417 (2011). Anthropometry, gestational weight gain, percentage of body fat mass and concentration of leptin plasma concentration were performed at the first, second and third trimesters of pregnancy. Statistical analyses were carried out using «Statistica 6.0». We demonstrated the association between elevated levels of leptin and gestational weight gain in all pregnant women in spite of prepregnancy body weight. The strongest dynamics of leptin increase was observed in normal weight women with excessive gestational weight gain: progression of hyperleptinemia during pregnancy was more intensive than in overweight. Higher second trimester leptin levels were positive associated with a greater subsequent weight gain and percentage of body fat mass, especially expressed in excessive weight gain women. The development of leptin resistance in these patients may be as a trigger for postpartum weight retention, overweight and obesity.


Zheng Z, Bennett WL, Mueller NT, et al. J Womens Health (Larchmt) 2018; 19. .

Goldstein RF, Abell SK, Ranasinha S, et al. BMC Med 2018; 16(1): 153. .

Logan CA, Bornemann R, Koenig W, et al. Sci Reports 2017; 2(7). .

Sбmano R, Martнnez-Rojano H, Chico-Barba G. Nutrients 2017; 9: 1067.

Ibrahim HS, Omar E, Froemming GR, Singh HJ. Biomed Res Int 2013. .

Farley DM, Choi J, Dudley DJ, et al. Placenta 2010; 31: 718-724. .

Vernini JM, Moreli JB, Araъjo Costa RA, et al. Diabetol Metab Syndr 2016; 8: 68.

Martinsa MC, Faleirob LL, Fonsecaa A. Rev Port Cardiol 2012; 31(11): 711-719.

Pйrez-Pйrez A, Toro A, Vilariсo-Garcнa T. J Cell Mol Med 2018; 22(2): 716-727. .

Rasmussen KM, Yaktine AL. IOM, Weight Gain During Pregnancy: Reexamining the Guidelines. Institute of Medicine and National Research Council of the National Academies, Committee to Reexamine IOM Pregnancy Weight Guidelines, Food and Nutrition Board on Children, Youth, and Families, Washington, 2009.

Nakaz MOZ Ukrai’ny, 15.07.2011; 417.

Staelens AS, Vonck S, Molenberghs G, et al. Eur J Obstet Gynecol Reprod Biol 2 016; 2 04: 6 9-73. .

Walsh JM, McGowan CA, Mahony RM, et al. Obesity (Silver Spring) 2 014; 2 2: 1 594-1600. 0.1002/oby.20753 .

Lacroix M, Battista M, Doyon M, et al. BMC Pregnancy and Childbirth 2016; 16: 62.




How to Cite

Ostafiichuk, S. O., & Henyk, N. I. (2019). Association of hypertleptinemia and gestational weight gain . Problems of Endocrine Pathology, 69(3), 52-58.