INFLUENCE METFORMIN ON THE STATE OF THE ANTIOXIDANT SYSTEM IN PATIENTS WITH NEWLY DIABETES MELLITUS TYPE 2

Authors

  • Zherdоva N. M. P. L. Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine; Сenter for Innovative Medical Technologies the NAS of Ukraine, Kyiv, Ukraine;
  • Mankovsky B. M. P. L. Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine; Сenter for Innovative Medical Technologies the NAS of Ukraine, Kyiv, Ukraine;
  • Lisun Y. B. Сenter for Innovative Medical Technologies the NAS of Ukraine, Kyiv, Ukraine;
  • Drevitskaya T. I. Bogomoletz Institute of Physiology, NAS of Ukraine, Kyiv, Ukraine;
  • Kostitska I. M. Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2019.4.06

Keywords:

newly diabetes mellitus type 2, antioxidant system, metformin.

Abstract

The article presents data on the state of the antioxidant system in patients with newly diabetes mellitus
type 2. The aim of our work was to determine the effect of metformin on the state of the antioxidant system
in patients with newly diagnosed type 2 diabetes. The study included 60 patients with newly diagnosed type 2
diabetes mellitus (43 women and 17 men). The average age of the patients was 60.91 ± 1.42 years, the level of
HbA1c was 7.91 ± 0.17 %. It was found that at the time of diagnosis of diabetes mellitus, a decrease in the level
of indicators of the antioxidant defense system, namely catalase by 3.5 times and glutathione peroxidase by
1.7 times in comparison with the control group, was already detected. After the course of treatment with metformin in the maximum tolerated dose (the average dose was 2000 mg per day), we received not only an improvement in metabolic control, namely a decrease in the level of glycated hemoglobin to 6.63 ± 0.11 % (p ≤ 0.05), but
also already after 3 months of treatment, improving the status of the antioxidant defense system by increasing
the levels of catalase and glutathione peroxidase enzymes, and therefore leads to a decrease in oxidative stress
and, as a result, a decrease in the development of complications of type 2 diabetes. In the study, we used three
metformin of various manufacturers as the first line of treatment in patients with newly diagnosed diabetes and
did not receive a significant difference in metabolic control, pro and antioxidant systems

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Published

2019-11-11

How to Cite

Жердьова, Н. М., Маньковський, Б. М., Лісун, Ю. Б., Древицька, Т. І., & Костицька, І. М. (2019). INFLUENCE METFORMIN ON THE STATE OF THE ANTIOXIDANT SYSTEM IN PATIENTS WITH NEWLY DIABETES MELLITUS TYPE 2. Problems of Endocrine Pathology, 70(4), 45-51. https://doi.org/10.21856/j-PEP.2019.4.06

Issue

Section

CLINICAL ENDOCRINOLOGY