EVALUATION OF HEART FAILURE WITH PRESERVED EJECTION FRACTION IN PATIENTS WITH CORONARY HEART DISEASE AND TYPE 2 DIABETES MELLITUS

Authors

  • Bilchenko O.V. Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
  • Lipakova K. Y. Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
  • Rudenko T. A. Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
  • Vysotska О.V. National Aerospace University – «Kharkiv Aviation Institute»; Kharkiv, Ukraine
  • A. P. Porvan National Aerospace University – «Kharkiv Aviation Institute»; Kharkiv, Ukraine
  • Karami Saliba D. Y. Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2020.1.01

Keywords:

coronary heart disease, type 2 diabetes mellitus, chronic heart failure, prognosis of the course, preserved ejection fraction.

Abstract

The aim is to develop a method for predicting the course of heart failure (HF) in patients with coronary heart disease (CHD) in combination with type 2 diabetes mellitus (DM). The study included 100 men aged 50 to 67 years with CHD in combination with type 2 DM. Patients were divided into two groups depending on the course of HF: I (n = 66) — with a favorable course, II (n = 34) — with an unfavorable course (decreased LV EF, patients with impaired diastolic function, and those who died during the year of observation). Analysis of cardiovascular anamnesis and indicators of carbohydrate and lipid metabolism were conducted; a transthoracic echocardiography was performed; endothelium-dependent dilation of the brachial artery (EDD) was studied. The Mann-Whitney U-test was used to determine the differences between independent samples, and the logistic regression method was used for prognosis. On the basis of the conducted research, a method for determining the prognosis of HF during a year in patients with coronary heart disease in combination with type 2 DM is proposed, by which, through additional research and determination of clinical and laboratory features with subsequent calculation, the prediction is achieved. For prognosis and subsequent calculation the formula using coefficients for prognostic factors, it is necessary to study EDD, arterial blood pressure with a calculation of pulse pressure, determine serum insulin with the calculation of the HOMA index, and use the regression equation with a high level of sensitivity and specificity to determine the probability of an adverse course of HF in patients with preserved ejection fraction.

References

Ametov AS, Kurochkin IO, Zubkov AA. Rus Med Zhurn 2014; 13: 954.

Kuharenko SS, Jadrihinskaja MN, Drozdova EN, et al. Problemy Jendokrinologii. 2016; 62(6): 10-19.

MacDonald MR, Petrie MC, Varyani F, et al. Eur Heart J 2008; 29: 137-138. doi: http://dx.doi.org/10.1093/eurheartj/ehn153.

Andreas М, Zeisler Н, Handisurya A, et al. Cardiovasc Diabetol 2011; 10: 28. doi: http://dx.doi.org/10.1186/1475-2840-10-22.

Vysotska O, Dobrorodnia H, Gordiyenko N, et al. Eastern-Eur J Enterprise Technol 2016; 6(2): 15-23. doi: http://dx.doi.org/10.15587/1729-4061.2016.85390.

Georgiyants MA, Khvysyuk OM, Boguslavska NM, et al. Eastern-Eur J Enterprise Technol 2017; 2 (4-86): 4-9. doi: http://dx.doi.org/10.15587/1729-061.2017.95157.

Rysovana L, Vysotska O, Falyova H, et al. Eastern-Eur J Enterprise Technol 2017; 1 (4-85): 40-49. doi: http://dx.doi.org/10.15587/1729-4061.2017.91428.

Ponikowski P, Voors AA, Anker SD, et al. Eur Heart J 2016; 37 (27): 2129-2200. doi: http://dx.doi.org/10.1093/eurheartj/ehw128.

Celermajer DS, Sorenson KE, Gooch VM, et al. Lancet 1992; 340: 1111-1115.

Hosmer DW, Lemeshow S. Applied logistic regression. Wiley series in probability and statistics. NY: A Wiley – Interscience Publication, 2015: 397 p.

Sandesara PB, O’Neal WT, Kelli HM et al. Diabetes Care 2018; 41 (1): 150-155. doi: http://dx.doi.org/10.2337/dc17-0755.

Solomahina NI, Belenkov JuN. Serdechnaja Nedostatochnost’ 2010; 5: 281-284.

Patent 11456. Sposіb prognozuvannja sercevoї nedostatnostі u hvorih na іshemіchnu hvorobu sercja.

Downloads

Published

2021-07-05

How to Cite

Bilchenko, O., Lipakova, K. Y., Rudenko, T. A., Vysotska О., Porvan, A. P., & Karami Saliba, D. Y. (2021). EVALUATION OF HEART FAILURE WITH PRESERVED EJECTION FRACTION IN PATIENTS WITH CORONARY HEART DISEASE AND TYPE 2 DIABETES MELLITUS. Problems of Endocrine Pathology, 71(1), 7-13. https://doi.org/10.21856/j-PEP.2020.1.01

Issue

Section

CLINICAL ENDOCRINOLOGY