THE CONDITION OF THE REPRODUCTIVE SYSTEM OF THE MATURE FEMALES OFFSPRING BORN TO MOTHERS WITH PLACENTAL INSUFFICIENCY
Keywords:fetoplacental insufficiency, young and mature mothers, female offspring, reproductive system
Embryonic period is the first crucial period of female reproductive system developing. Specifically, at this
period egg cells of future woman start forming in her mother's uterine and continue developing up to the moment
when mature egg cell merges with sperm cell forming zygote. The connection between mother's organism
and fetus during pregnancy depends on placenta condition; the fetoplacental complex is the functional system
which provides essential conditions for fetal developing. The disturbances of this complex may cause fetoplacental
insufficiency (FPI). Placental structure and functioning may be adapted to different external stressors.
In case of failed adaptation or abnormal placental maturating the healthy child birth is under threat and may
cause a developing of adult’s diseases in future. These days, the number of reproductive-aged women giving
birth at later age is growing. This fact influences on the fertilization, pregnancy, delivery, developing and child
functioning. The purpose of this investigation was the studying of the influence of FPI long-term consequences
on the reproductive system functioning of mature female offspring born to different-aged mothers. Materials.
The healthy, mature rat's females-mothers Vistar line, young and mature reproductive age have been used in
the investigation. With the aim to receive the offspring, four experimental groups of animals have been formed.
The firs and the second group were performed by intact animals of relevant age. Rat’s females with experimental
FPI of young and mature reproductive age have been united into third and fourth groups accordingly. The
modeling of FPI has been carried out by daily subcutaneous introduction of 50 % tetrachloromethane oil solution
in dose of 2 ml/kg of body weight to females from 12 to 18 day of pregnancy. After offspring birth the reproductive
function of rat’s females in the age of 3 months has been researched. Results. Under the influence of experimental
fetoplacental insufficiency and higher testosterone level, the decreasing of ovaries mass and number
of follicles have been observed in female offspring born to mothers of young reproductive age. On the contrary,
ovaries mass and number of follicles in female offspring born to mothers of mature reproductive age with FPI
and high testosterone level haven’t changed compared to intact group. Although, estrus cycles duration and
structure haven’t changed under the condition of FPI in both age groups, there were offspring with irregular
estrus cycles. These changes in the reproductive system of female offspring may lead to endocrine infertility as
well as other reproductive disorders.
Loomans EM, et al. Eur J Public Health 2013; 23(3): 485-491. doi: http://doi.org/10.1093/eurpub/cks097.
Entringer S, de Punder K, Buss C, Wadhwa PD. Philos Trans R Soc Lond B Biol Sci 2018; 373(1741): pii:20170151. doi: http://doi.org/10.1098/rstb.2017.0151.
Vieten C, Astin J. Arch Womens Ment Health 2008; 11:67-74. doi: http://doi.org/10.1007/s00737-008-0214-3.
Serdjuk AM, Tymchenko OI, Pokanevych TM, et al. Med Perspektyvy 2002; 7(1): 138-142.
Gorina OV, Galagan VO, Tymchenko OI, Kryvych IP. Visnyk organizacii’ ohorony zdorov’ja 2003; 3: 11-14.
Serdjuk AM, Tymchenko OI, Lynchak OV, et al. Zhurn AMN Ukrai’ny 2009; 15(1): 146-155.
Asherson RA. The Catastrophic Antiphospholipid Syndrome (Asherson’s Syndrome), Johannesburg, 2005: 539 p.
Shapovalenko SA. Vestn Ros assoc akusherov-ginekologov 2001; 2: 43-47.
Kalinovs’ka IV. Klinichna ta eksperymental’na patologija 2007; 6(2): 42-44.
Stasenko T. Ukr med chasopys 2016; 3(113).
Davydov AI, Strizhakova MA, Orlov ON. Voprosy ginekologii, akusherstva i perinatologii 2004; 3(6): 84-89.
Filippov OS, Kazanceva AA. Problemy Reprodukcii 2007; 3: 60-63.
Verhovna Rada Ukrai’ny. Jevropejs’ka konvencija pro zahyst hrebetnyh tvaryn, shho vykorystovujut’sja dlja doslidnyc’kyh abo inshyh naukovyh cilej vid 18.03.1986, available at:
Polozhennja pro Komitet z pytan etyky (bioetyky): Nakaz № 1287 vid 19.11.2012, available at: http://www.mon.gov.ua/ua/activity/63/64/normativno-pravova-baza/.
O’Brien Y, Wingfield MB, et al. Ir J Med Sci 2019;188(1): 161-167. doi: http://doi.org/10.1007/s11845-018-1769-2.
Seliukova NYu, Misjura KV. Probl Endokryn Patologii’ 2019; 4: 130-142.
Kocabin NV, Makarchuk OM. Zdorov’e Zhenshhiny 2015; 5(101): 150-153.
Clarke HJ. Wiley Interdiscip Rev Dev Biol 2018; 7(1). doi: http://doi.org/10.1002/wdev.294.
Andersen CY, Ezcurra D. Reprod Biol Endocrinol 2014;12: 128. doi: http://doi.org/10.1186/1477-7827-12-128.