MORPHOMETRIC PARAMETERS OF MESENTERIC FAT TISSUE AND THEIR CHANGE UNDER THE INFLUENCE OF STRESS FACTORS IN RATS-OFFSPRING OF GESTATIONAL STRESSED MOTHERS
Keywords:gestational stress, offspring, obesity, fat tissue, adipocytes
The work is devoted to the study of the influence of socio-emotional stress of mothers at different stages of
pregnancy on the formation of adipose tissue in female offspring in adulthood, the detection of the presence and
nature of the influence of additional stress factors on morphofunctional characteristics of adipose tissue in these
animals. In an experiment on Wistar rats population, body weight, visceral and separately mesenteric adipose tissue weight in 12-month-old offspring of gestational stressed mothers were determined. It has been shown that
adult offspring of stressed mothers have increased body weight and visceral adipose tissue mass compared to
offspring of intact mothers. A comparative study of morphometric data of mesenteric adipose tissue in female
rats — offspring of intact and gestational stressed mothers in a state of physiological rest and after action of
stress factors was carried out. Thus, it can be said that already in a state of physiological rest there are quantitative
and qualitative differences between the cellular composition of mesenteric adipose tissue of intact
(control) and test female offspring. Additional stress in the adult state particularly clearly affected the cellular
composition and its characteristics in offspring of gestational stressed females. There has been an increase in
the number of average size adipocytes in gr C-1s with a simultaneous expressive increase in the number of large
and very large adipocytes, indicating the development of hypertrophic obesity in animals of this group. At the
same time, the prevalence of the percentage of small and medium adipocytes in gr C-3s after exposure to stress
factors indicates active hyperplastic processes in the mesenteric adipose tissue of these rats. The manifestation
of hyperplasia activity is also the appearance of numerous small size adipocyte formations in the adipose tissue
of this group of descendants. It has been found that stress of sexually mature offspring leads to the formation of
a hypertrophic type of obesity in intact animals and offspring of mothers stressed in the first trimester of pregnancy and provokes hyperplasia of adipocytes and the appearance of signs of inflammation of adipose tissue in rats stressed in the antenna period.
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