HYPOPINEALISM AND ARTERIAL HYPERTENSION: CHRONOBIOLOGICAL AND AGE ASPECTS

Authors

  • Mishchenko Т. V. N. Karazin Kharkiv National University, Kharkiv, Ukraine;State Institution «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine
  • Bondarenko L. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2020.1.14

Keywords:

hypopinealism, arterial hypertension, circadian rhythm, blood pressure

Abstract

The research is done on the mature male rabbits divided into three groups: mature animals (group I), old
animals (group II), and mature animals with hypopinealism (group III). The rabbits in the Ist and IInd group
were kept in the natural light conditions (the former ones for a period of 10 months and the latter ones for
3 years and a half). Hypopinealism was induced in rabbits (group III) by 24-hour lighting for 10 months. Blood
pressure was measured on the animals’ central ear artery four times a day (in the morning [from 07:00 a.m.
until 08:00 a.m.], in the afternoon [from 01:00 p.m. until 02:00 p.m.], in the evening [from 07:00 p.m. until
08:00 p.m.] and at night [from 01:00 a.m. until 02:00 a.m.]) every month. The blood pressure circadian rhythm
was analyzed on the basis of the quantities of acrophase, batiphase, mesor, amplitude, degree of blood pressure
reducing. It was revealed that the blood pressure indices in the rabbits with hypopinealism and in the old
animals were similar during the day, but the quantities exceeded corresponding values in the mature animals.
Moreover, the indices of blood pressure circadian rhythm in the rabbits with hypopinealism and in the old animals
show leveling of the biphasic circadian pattern of the parameter identified in the mature rabbits. Thereby,
hypopinealism (induced by age or long-lasting 24-hour lighting) causes the development of arterial hypertension
of «non-dipper» type in the rabbits. Consequently, formation of hypertension against hypopinealism induced by
the long-lasting low-intensity light exposure during the darkness is one of the animal senilism symptoms.

References

Korkushko OV, Bondarenko LO, Shatylo VB, et al. Zhurn AMN Ukrai’ny 2008; 14(2): 373-381.

Anisimov VN. Uspehi Fiziologicheskih Nauk 2008; 39(4):52-76.

Tsang AH, Barclay J, Oster H. J Mol Endocrinol 2014;52(1): 16-32.

Shatilo VB, Antonjuk-Shheglova IA, Bondarenko EV, et al. Krovoobig ta Gemostaz 2007; 4: 18-25.

Bondarenko LA, Mishhenko TV. Patologicheskaja Fiziologija i Jeksperimental’naja Terapija 2015; 1: 46-49.

Gubina-Vakulik GI, Bondarenko LA, Sotnik NN. Uspehi Gerontologii 2007; 1: 92-95.

Patent 83426 UA. Pristrіj dlja vimіrjuvannja arterіal’nogo tisku u krolіv.

Brainard GC, Richardson BA, King TS, et al. Brain Res 1984; 5: 333-339.

Van den Buuse M, Malpas SC. Physiol Behav 1997; №62(1). Р. 83–89.

Viera AJ, Zhu S, Hinderliter AL, et al. J Am Soc Hypertens 2011; 5(1): 48-55. doi: http://doi.org/10.1016/j.jash.2010.12.002.

Lee DH, Ihm SH, Youn HJ. Korean Circ J 2009; 39(8):322-327. doi: http://doi.org/10.4070/kcj.2009.39.8.322.

Bondarenko LO, Kondakov IK, Gladkova AI, et al. Bukov Med Visn 2009; 13(4): 41-45.

Simko F, Reiter RJ, Pechanova O. et al. Front Biosci 2013; 18: 616-625.

Bondarenko LA, Gorbach TV, Kozak VA. Uspehi Gerontologii 2014; 27(4): 625-630.

Mishhenko TV, Gladkyh OI, Poltorak VV, Bondarenko LO. Endokrynologija 2015; 2: 494-500.

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Published

2021-07-05

How to Cite

Mishchenko Т. ., & Bondarenko, . L. . (2021). HYPOPINEALISM AND ARTERIAL HYPERTENSION: CHRONOBIOLOGICAL AND AGE ASPECTS. Problems of Endocrine Pathology, 71(1), 105-110. https://doi.org/10.21856/j-PEP.2020.1.14