TELOMERE LENGTH, TELOMERASE ACTIVITY AND OXIDATIVE STRESS IN ELDERLY WITH CHRONIC CEREBROVASCULAR DISEASES*

Authors

  • Cherska M. SI «V. P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kyiv, Ukraine
  • Krasnienkov D. SI «D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine», Kyiv, Ukraine
  • Guryanov V. Bogomolets National Medical University, Kyiv, Ukraine
  • Kukharskyy V. SI «D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine», Kyiv, Ukraine
  • Tronko N. SI «V. P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine», Kyiv, Ukraine;
  • Kondratiuk V. Bogomolets National Medical University, Kyiv, Ukraine
  • Zabuga O. SI «D. F. Chebotarev Institute of Gerontology of the NAMS of Ukraine», Kyiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2020.2.10

Keywords:

cerebrovascular diseases, oxidative stress, telomerase activity, telomere length.

Abstract

Background. Clarification of the mechanisms of biochemical changes in the development of cerebrovascular diseases is the one of the main problems of modern medicine.
The aim of our study is to determine the relationship of telomere length and telomerase activity with indicators of oxidative stress in patients with cerebral atherosclerosis (CA) and diabetes mellitus.
Methods. The clinical and instrumental study involved 86 patients with CA.
Results. The patients were divided twice into the 2 groups depending on the relative telomere length and
telomerase activity. It has been found that the patients with CA with long telomeres have statistically significantly higher level of catalase (CAT) comparing to those from the group with short telomeres. Also, in the group
with high telomerase activity the CAT and superoxide dismutase (SOD) levels are statistically significantly
lower than in the group with low telomerase activity. It should be noted that the patients with long and short
telomeres are comparable in age, and the age of the patients with low telomerase activity statistically significantly greater.
Conclusions. In the patients with CA the association of some markers of oxidative stress (CAT, SOD, glutathione (GSH)) with telomere length and telomerase activity has been detected, regardless of the presence of
concomitant diabetes mellitus. The most stable direct correlation in this category of the patients has been found
between GSH and telomerase activity (r = 0.48), that may indicate the key role of GSH in the rate of telomere
shortening and the development of atherosclerosis.

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Published

2021-06-30

How to Cite

Cherska, M. . ., Krasnienkov, D. ., Guryanov, V., Kukharskyy, V. K., Tronko, N. . ., Kondratiuk, V. . ., & Zabuga, O. . (2021). TELOMERE LENGTH, TELOMERASE ACTIVITY AND OXIDATIVE STRESS IN ELDERLY WITH CHRONIC CEREBROVASCULAR DISEASES*. Problems of Endocrine Pathology, 72(2), 81-88. https://doi.org/10.21856/j-PEP.2020.2.10

Issue

Section

CLINICAL ENDOCRINOLOGY