THE CORRECTION OF THE CONSEQUENCES OF THE EXPERIMENTAL PROSTATITIS BY NANOPARTICLES OF ORTHOVANADATES OF THE RARE-EARTH ELEMENTS
Keywords:experimental chronic prostatitis, nanoparticles of silver and rare-earth metals, spermogram, testosterone
The management of patients with chronic prostatitis (CP) remains the difficult medical and social problem that makes the elaboration of new prostate protectors actual. The purpose of the work: to ascertain the effectiveness of nanoparticles' of rare-earth elements with different form-factors correction of the pathological seminal's endocrine and spermatogenic function disturbances caused by chronic experimental prostatitis. The modeling of CP in mature rats’ males has been fulfilled using Wartner device by cryo trauma of the prostate gland making. The compositions of nanoparticles (NP) of rare-earth metals (LaVO4 or GdVO4 ) activated by Europium, with NP Ag added, in shape of rods, spheres and grains have been chosen for CP correction. The dose was 0,3 mg/kg of body weight. The drug of comparison was 0,5 % «Prostatilen». The researched substances have been rectally introduced in volume of 0,5 ml from 15th after surgery during next two weeks. The number of leukocytes in blood, condition and masses of the prostate gland and seminal vesicles, the concentration of the general testosterone and spermatogenesis indices have been determined. It has been determined that using of NP composition based on the oxides of rare-earth elements and NP Ag (nanorods) for pathology correction has declined consequences of CP: the general inflammation has been substantially inhibited, mass coefficients of the epididymis and testosterone level have been recovered and spermatogenesis have been improved. For some spermogram indices, the activity of these NP does not concede, but even exceeds the activity of drug of comparison. The using of NP GdVO4:Eu3+ + Ag in the spherical shape has positively influenced the correction of chronic prostatitis, although the effectiveness was less distinct. Thus, the composition of nanoparticles LaVO4:Eu3+ + Ag in the form of rods has a positive effect on the sexual function of rats with chronic prostatitis compared with the effect of nanoparticles GdVO4:Eu3++Ag in the form of spheres or grains.
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