Remote hormonal effects of cystic mole and ways of their solution


  • Lazurenko V. V. Kharkiv National Medical University, Kharkiv, Ukraine
  • Pasieshvili N. M. Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
  • Karpenko V. G. Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
  • Starkova I. V. Kharkiv National Medical University, Kharkiv, Ukraine



cystic mole, disturbances of a menstrual cycle, rehabilitation


Cystic mole affects various links of endocrine system, stipulating numerous modifications in a female organism and reproductive system, in particular. The purpose of our work was to study the state of menstrual function and to develop methods of its rehabilitation in the women who had cystic mole in their past. 37 women who had cystic mole 1–10 years ago were investigated. The first clinical group included 20 patients who received a complex herbal drug as rehabilitation; the second group consisted of 17 women, they had standard observation of once or twice a year. In addition, with the use of randomized method there was separated the control group (20 healthy women of reproductive age representing the observation part of study design). In the course of the study it has been found out that the tolerated cystic mole results to an unbalance of estradiol and progesterone, produced by ovaries, and it stipulates the disturbance of a menstrual cycle in 45.9 % of cases which show an absence of regular bleedings, an oligomenorrhea or alternating of poor and profuse bleedings. The use of a complex herbal drug after cystic mole within three months eliminates pathological levels of estradiol and progesterone and results in normalizing of a menstrual cycle.


Al-Talib AA. J Fam Community Med 2016; 23(3): 161-165.

Savage PM, Sita-Lumsden A, Dickson S, et al. J Obstet Gynaecol 2013; 33(4): 406-411. .

Joneborg U, Marions L. J Reprod Med 2014; 59(1-2): 51-55.

Ito Y, Maehara K, Kaneki E. Gynecol Obstet Invest 2016; 81(4): 353-358. .

Eagan D, Jeter N. Case Rep Womens Health 2016; 12: 11-14. .

Mempin MV, Desai P, Shaukat NM. Emergency Med 2017; 49(1): 41-42.

Bhat S, Maletkovic J. Clin Thyroid Arch 2013; 25(12): 298-300.

Virmani S, Srinivas SB, Bhat R, et al. J Clin Diagn Res 2017; 11(7): 1-2. .

Agarwal R, Teoh S, Short D, et al. Lancet 2012; 14(379): 130-135. .

Nosenko EN, Rutinskaja AV. Zdorov’e Zhenshhiny 2011; 1(57): 209-215.

Dugina LV, Kijko NS. Fizychna reabilitacija ta rekreacijnoozdorovchi tehnologii’ 2016; 2: 11-13.

Kornac’ka AG, Chubej GV, Brazhuk MV, et al. Zdorov’e Zhenshhiny 2014; 3(89): 123-126.

Shapoval OS. Nauk visn Uzhgorod un-tu, serija «Medycyna» 2016; 2(54): 164-168.




How to Cite

Lazurenko, V. V., Pasieshvili, N. M., Karpenko, V. G., & Starkova, I. V. (2019). Remote hormonal effects of cystic mole and ways of their solution. Problems of Endocrine Pathology, 69(3), 29-34.




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