PECULIARITIES OF HORMONAL REGULATION OF REPRODUCTIVE FUNCTION IN PATIENTS WITH EJACULATORY DUCT OBSTRUCTION

Authors

  • Lisovyi V. M. Kharkiv National Medical University, Kharkiv, Ukraine MHI «V. I. Shapoval Regional Medical Clinical Center of Urology and Nephrology», Kharkiv, Ukraine
  • Panasovskyi M. L. MHI «V. I. Shapoval Regional Medical Clinical Center of Urology and Nephrology», Kharkiv, Ukraine
  • Arkatov A. V. MHI «V. I. Shapoval Regional Medical Clinical Center of Urology and Nephrology», Kharkiv, Ukraine
  • Harahatyi I. A. MHI «V. I. Shapoval Regional Medical Clinical Center of Urology and Nephrology», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2020.2.08

Keywords:

male infertility, ejaculatory duct obstruction, androgen deficiency, endocrine disorders.

Abstract

Materials. 137 patients were divided into two clinical groups: the first (main) group consisted of 103 patients
with male infertility due to EDO, and the second (control) group included 34 practically healthy men.
Results. The study of globulin concentration binding sex hormones showed its increase in men of the
main group within 26.7 ± 12.5 %, compared with the control group 27.1 ± 9.2 nmol/l versus 21.3 ± 3.9 nmol/l,
respectively (p = 0.406483). The mean indicator of androgen index in patients with EDO was at the lower limits
of the norm and made up 70 %, amounting to 84.3 ± 19.8 % compared with 110.8 ± 11.5 % in the control group
(p = 0.085391). The average concentration of gonadotropins was slightly higher in the patients with EDO compared
with practically healthy men, but within the statistical error. The corresponding values of FSH and LH
were 4.1 ± 2.1 and 5.1 ± 3.9 mIU/ml versus 3.5 ± 1.8 and 4.4 ± 1.7 mIU/ml in the control group (p > 0.05). There
were no differences in the content of BPD which was 239.5 ± 82.6 versus 234.2 ± 75.7 mIU/ml, (p > 0.05).
Conclusions. 22.3 % of patients with EDO had a hidden or relative androgen deficiency, characterized by
70 % decrease in AI at the corresponding normal levels of total T on the background of increasing SHBG concentration,
influenced by the age changes (older than 40 years, χ2 = 34.05; p < 0.001), previously cured orchid or
epididymitis (χ2 = 5.06; p < 0.025), and additional marker of unrealized reproductive function (lack of pregnancy
in sexual partners: χ2 = 7.96; p < 0.005). There was no reliable relationship between relative androgen deficiency
and the incidence of prostatitis in anamnesis (χ2 = 2.99; p > 0.05). The fact of previously cured prostatitis did
not affect the frequency of AI reduction in patients with EDO. The highlighted peculiarities of the hormonal
profile in patients with EDO confirmed the secondary (acquired) nature of the genesis of ejaculatory duct obstruction.
They also showed that this pathology had a tendency to gradually suppress the function of the testes
and form androgen deficiency proved by lower AI.

References

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Published

2021-06-30

How to Cite

Lisovyi, V. M. ., Panasovskyi, M. L. . ., Arkatov, A. V. . ., & Harahatyi, I. A. . . (2021). PECULIARITIES OF HORMONAL REGULATION OF REPRODUCTIVE FUNCTION IN PATIENTS WITH EJACULATORY DUCT OBSTRUCTION. Problems of Endocrine Pathology, 72(2), 66-73. https://doi.org/10.21856/j-PEP.2020.2.08

Issue

Section

CLINICAL ENDOCRINOLOGY