Influence metformin on state cognitive function in patients with newly diabetes mellitus type

Authors

  • Zherdova N. N. P. L. Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine; Center for Innovative Medical Technologies of NAS of Ukraine, Kyiv, Ukraine
  • Mankovsky B. N. P. L. Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine; Center for Innovative Medical Technologies of NAS of Ukraine, Kyiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2019.3.01

Keywords:

newly diabetes mellitus, cognitive function, memory, metformin

Abstract

The article provides data on the concerning state of cognitive function on data various neuropsychological tests in patients with newly diabetes mellitus type 2. The study included 60 patients with newly diabetes mel litus type 2. The state of cognitive functions was determined using standard psychoneurometric tests adjusted for age and educational level. It has been found that at time diagnosis diabetes, there was a decrease cognitive function. Metformin administration, after 3 months of treatment, statistical significant improved the state of short-term and long-term memory.

References

Lin Y, Wang K, Ma C, et al. Front Aging Neurosci 2018; 10: 227. https://doi.org/10.3389/fnagi.2018.00227.

Pashkovs’ka N.V. Mizhnar endokrynol zhurn 2018;1: 76-85.

Pintana H, Apaijai N, Pratchayasakul W, et al. Life Sci 2012; 91(11-12): 409-414. https://doi.org/10.1016/j.lfs.2012.08.017 .

Markowicz-Piasecka M, Sikora J, Szyd owska A, et al. Davide Bramb Pharm Res 2017; 34(12): 2614-2627. https://doi.org/10.1007/s11095-017-2199-y .

Fatt M, Hsu K, He L, et al. Stem Cell Reports 2015; 5(6): 988-995. https://doi.org/10.1016/j.stemcr.2015.10.014 .

Zherd’ova NM, Man’kovs’kyj BM. Probl Endokryn Patologii’ 2018; 1: 22-28.

Cheng C, Lin CH, Tsai YW, et al. J Gerontol Biol Med Sci 2014; 69(10): 1299-1305. https://doi.org/10.1093/gerona/glu073 .

Koekkoek PS, Kappelle LJ, van den Berg E, et al. Lancet Neurol 2015;14: 329-340. https://doi.org/10.1016/S1474-4422(14)70249-2 .

Hwang IK, Kim IY, Joo EJ, et al. Seong Neurochem Res 2010; 35(4): 645-650. https://doi.org/10.1007/s11064-009-0115-5 .

Hsu CC, Wahlqvist ML, Lee MS, Tsai HN. J Alzheimers Dis 2011; 24(3): 485-493. https://doi.org/10.3233/JAD-2011-101524 .

Luchsinger JA, Perez T, Chang H, et al. J Alzheimers Dis 2016; 51(2): 501-514. https://doi.org/10.3233/JAD-150493 .

Koenig AM, Mechanic-hamilton D, Xie SX, et al. Alzheimer Dis Assoc Disord 2017; 31(2): 107-113. https://doi.org/10.1097/WAD.0000000000000202 .

Downloads

Published

2019-08-28

How to Cite

Zherdova, N. N., & Mankovsky, B. N. (2019). Influence metformin on state cognitive function in patients with newly diabetes mellitus type. Problems of Endocrine Pathology, 69(3), 7-13. https://doi.org/10.21856/j-PEP.2019.3.01

Issue

Section

CLINICAL ENDOCRINOLOGY