FEATURES OF FREE RADICAL OXIDATION AND ANTIOXIDANT PROTECTION IN ADOLESCENT BOYS WITH HYPOANDROGENISM DEPENDING ON THE FUNCTIONAL CONDITION OF THE THYROID GLAND

Authors

  • Kashkalda D. A. SI «Institute for Children and Adolescents Health Care of the NAMS of Ukraine», Kharkiv, Ukraine
  • Kosovtsova G. V. SI «Institute for Children and Adolescents Health Care of the NAMS of Ukraine», Kharkiv, Ukraine; V. N. Karazin Kharkiv National University, Kharkiv, Ukraine
  • Turchina S. I. SI «Institute for Children and Adolescents Health Care of the NAMS of Ukraine», Kharkiv, Ukraine; V. N. Karazin Kharkiv National University, Kharkiv, Ukraine; Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
  • Sukhova L. L. SI «Institute for Children and Adolescents Health Care of the NAMS of Ukraine», Kharkiv, Ukraine
  • Sotnikova-Meleshkina Zh. V. V. N. Karazin Kharkiv National University, Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2020.1.04

Keywords:

adolescent boys, hypoandrogenism, thyroid condition, free radical oxidation, antioxidant protection

Abstract

We examined 36 boys aged 13–18 years with hypoandrogenism, who studied the indicators of free radical oxidation and antioxidant protection, depending on the TSH level and the TSH/fT4 ratio. The control group consisted of 84 boys of similar age. It was found that in adolescent boys with hypoandrogenism, a significant role in the mechanisms of the development of stress response belongs to the thyroid gland. In turn, disorders of redox processes exacerbate the severity of hypothyroidism, form a state of oxidative stress, the main initiator of which is the low activity of the main enzyme antioxidant protection — glutathione peroxidase. Thyroid dysfunction in patients with androgen deficiency leads to an imbalance of key antioxidant enzymes. In half of adolescents with subclinical hypothyroidism, the activity of catalase and superoxide dismutase increases, and the frequency of normal values decreases, in all — the activity of glutathione peroxidase decreases, and in 75 % of patients, the degree of oxidative stress increases. The relationship of the thyroid profile and oxidative changes was confirmed by the data of correlation analysis. The revealed features of changes in antioxidant protection indicators in adolescent boys allow pathogenetically substantiating the subsequent correction and prevention of antioxidant deficiency in the initial stages of hypoandrogenism in combination with hypothyroidism

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Published

2020-03-03

How to Cite

Kashkalda, D. A., Kosovtsova, G. V., Turchina, S. I., Sukhova, L. L., & Sotnikova-Meleshkina, Z. V. (2020). FEATURES OF FREE RADICAL OXIDATION AND ANTIOXIDANT PROTECTION IN ADOLESCENT BOYS WITH HYPOANDROGENISM DEPENDING ON THE FUNCTIONAL CONDITION OF THE THYROID GLAND. Problems of Endocrine Pathology, 71(1), 30-35. https://doi.org/10.21856/j-PEP.2020.1.04

Issue

Section

CLINICAL ENDOCRINOLOGY

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