PROGRESSION FACTORS OF AUTOIMMUNE THYROIDITIS IN YOUNG PEOPLE WITH GASTROESOPHAGE AL REFLUX DISE ASE: THE ROLE OF THE XENOBIOTIC DETOXIFICATION SYSTEM, MECHANISMS OF ENDOGENOUS CONTROL AND STIMULATION
Keywords:autoimmune thyroiditis, gastroesophageal reflux disease, antioxidant system, Klotho protein
The study involved patients with autoimmune thyroiditis and gastroesophageal reflux disease, which is due to the frequent occurrence of these nosologies at a young age. Purpose of the study was to clarify the mechanisms of endogenous control of the xenobiotic detoxification system in young patients with autoimmune thyroiditis and gastroesophageal reflux disease. The work involved 162 patients with autoimmune thyroiditis, which in 120 cases was combined with gastroesophageal reflux disease. The contingent of the surveyed was represented by students of the city's universities aged 18 to 25. Autoimmune thyroiditis was confirmed by the presence of antibodies to thyroperoxidase and thyroglobulin and by ultrasound of the thyroid gland. The functional state of the thyroid gland was assessed by the content of thyroid-stimulating hormone, free triiodothyronine and free thyroxine. The thyroid profile in the examined patients corresponded to euthyroidism. The diagnosis of gastroesophageal reflux disease was confirmed by tipical complaints, data from anamnesis, clinical and instrumental studies.The indicators of the second phase of the antioxidant system - glutathione peroxidase, glutathione reductase, manganese superoxide dismutase, and also the Klotho protein were studied. Licensed program Statistica Basic Academic 13 for Windows was used. It was found that the course of autoimmune thyroiditis and its combination with gastroesophageal reflux disease leads to the activation of the antioxidant defense system, which was manifested by a decrease in the synthesis of glutathione reductase and glutathione peroxidase. At the same time, a significant increase in the synthesis of the mitochondrial manganese superoxide dismutase, an indicator of the second phase of the xenobiotic detoxification system, was proved. The content of Klotho protein in patients with autoimmune thyroiditis had a tendency to increase and significantly increased in the case of comorbidity. Thus, the combined course of autoimmune thyroiditis and gastroesophageal reflux disease is accompanied by the inclusion of indicators of the second phase of the antioxidant system, which makes it possible to control the formation of toxic substances, and the simultaneous stimulation of manganese superoxide dismutase and Klotho protein provides endogenous control of antioxidant protection.
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